大手 学

Manabu Ote

慶應義塾大学 医学部 生物学教室 准教授

略歴

2004年3月
東京大学 大学院農学生命科学研究科 生産環境生物学専攻 博士後期課程 修了
2004年4月
早稲田大学 理工学総合研究所 助手
2006年4月
東北大学大学院 生命科学研究科 博士研究員
2011年4月
東北大学大学院 薬学研究科 助教
2014年10月
東北大学大学院 生命科学研究科 博士研究員
2016年4月
東京慈恵会医科大学 助教
2019年4月
東京慈恵会医科大学 講師
2026年4月
慶應義塾大学医学部 准教授

専門分野・所属学会

専門分野

所属学会

研究業績

原著論文（査読有）

  1. Development of a colorimetric RT-LAMP-based microfluidic device for SARS-CoV-2 detection.
    Tatsuya Sakurai, Hiroka Aonuma, Daigo Natsuhara, Tokio Hoshina, Manabu Ote, Erisha Saiki, Takayuki Shibata, Hirotaka Kanuka. Tropical Medicine and Health 54:25, 2026.
  2. Dissecting the dynamics of virus-derived DNA of dengue virus 2 (DENV-2) in Aedes mosquitoes.
    Hiroka Aonuma, Aboubacar Sombié, Jian-Chiuan Li, Manabu Ote, Erisha Saiki, Hidetoshi Ichimura, Itoe Iizuka, Taichi Odagawa, Tatsuya Sakurai, Kayoko Yamaji, Masayuki Saijo, Chun-Hong Chen, Athanase Badolo, Hirotaka Kanuka. PLoS One 20:e0332245, 2025.
  3. Three years of insecticide resistance evolution and associated mechanisms in Aedes aegypti populations of Ouagadougou, Burkina Faso.
    Félix Yaméogo, Aboubacar Sombié, Manabu Oté, Erisha Saiki, Tatsuya Sakurai, Dimitri W Wangrawa, Philip J McCall, David Weetman, Hirotaka Kanuka, Athanase Badolo. PLoS Neglected Tropical Diseases 18(12):e0012138, 2024.
  4. Wolbachia infection in Aedes aegypti does not affect its vectorial capacity for Dirofilaria immitis.
    Takahiro Shirozu, Maria Angenica F Regilme, Manabu Ote, Mizuki Sasaki, Akira Soga, Hiroki Bochimoto, Hidenobu Kawabata, Rika Umemiya-Shirafuji, Hirotaka Kanuka, Shinya Fukumoto. Scientific Reports 14:22528, 2024.
  5. DIPA-CRISPR gene editing in the yellow fever mosquito Aedes aegypti (Diptera: Culicidae).
    Yu Shirai, Momoyo Takahashi, Manabu Ote, Hirotaka Kanuka, Takaaki Daimon. Applied Entomology and Zoology 58:273–278, 2023.
  6. Association of 410L, 1016I and 1534C kdr mutations with pyrethroid resistance in Aedes aegypti from Ouagadougou, Burkina Faso, and development of a one-step multiplex PCR method for the simultaneous detection of 1534C and 1016I kdr mutations.
    Aboubacar Sombie, Wendegoudi Mathias Ouedraogo, Manabu Ote, Erisha Saiki, Tatsuya Sakurai, Felix Yameogo, Antoine Sanon, Philip J McCall, Hirotaka Kanuka, David Weetman, Athanase Badolo. Parasites and Vectors 16:137, 2023.
  7. Effectiveness of Rapid Antigen Testing in Forensic Cases of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Including Delta Variant.
    Sari Matsumoto, Shojiro Takasu, Suzuka Shimmura, Kyoko Iwadate, Ami Sakai, Yuko Kanto, Tatsuya Sakurai, Manabu Ote, Erisha Saiki, Hirotaka Kanuka, Kimiharu Iwadate. The American Journal of Forensic Medicine and Pathology 43:305–310, 2022.
  8. A human tissue-based assay identifies a novel carrion blowfly strain for maggot debridement therapy.
    Takuma Yoshida, Hiroka Aonuma, Saori Otsuka, Hidetoshi Ichimura, Erisha Saiki, Kosei Hashimoto, Manabu Ote, Sari Matsumoto, Kimiharu Iwadate, Takeshi Miyawaki, Hirotaka Kanuka. Scientific Reports 12:12191, 2022.
  9. LAMP Detection of Virus-Derived DNA of Zika Virus in Vector Mosquito.
    Hiroka Aonuma, Itoe Iizuka, Jian-Chiuan Li, Manabu Ote, Shigeru Tajima, Masayuki Saijo, Chun-Hong Chen, Hirotaka Kanuka. Frontiers in Tropical Diseases, 2022.
  10. Intensive diagnostic management of coronavirus disease 2019 (COVID-19) in academic settings in Japan: challenge and future.
    Tokio Hoshina, Hiroka Aonuma, Manabu Ote, Tatsuya Sakurai, Erisha Saiki, Yuki Kinjo, Kazuhiro Kondo, Masataka Okabe, Hirotaka Kanuka. Inflammation and Regeneration 40:38, 2020.
  11. Impact of Wolbachia infection on Drosophila female germline stem cells.
    Manabu Ote, Daisuke Yamamoto. Current Opinion in Insect Science 37:8–15, 2020.
  12. Calmodulin-binding transcription factor shapes the male courtship song in Drosophila.
    Md. Tanveer Ahsan, Kosei Sato, Manabu Ote, Masayuki Koganezawa, Daisuke Yamamoto. PLoS Genetics 15:e1008309, 2019.
  13. The Wolbachia protein TomO interacts with a host RNA to induce polarization defects in Drosophila oocytes.
    Manabu Ote, Daisuke Yamamoto. Archives of Insect Biochemistry and Physiology 99:e21475, 2018.
  14. A highly secure method for rearing Aedes aegypti mosquitoes.
    Manabu Ote, Hirotaka Kanuka. Tropical Medicine and Health 46:16, 2018. 共責任著者.
  15. Enhancing Nanos expression via the bacterial TomO protein is a conserved strategy used by the symbiont Wolbachia to fuel germ-stem cell maintenance in infected Drosophila females.
    Manabu Ote, Daisuke Yamamoto. Archives of Insect Biochemistry and Physiology 98:e21471, 2018.
  16. Expression of matrix metalloproteinase genes during basement membrane degradation in the metamorphosis of Bombyx mori.
    Hideki Kawasaki, Asaithambi Manickam, Rima Shahin, Manabu Ote, Masashi Iwanaga. Gene 638:26–35, 2017.
  17. Wolbachia Protein TomO Targets nanos mRNA and Restores Germ Stem Cells in Drosophila Sex-lethal Mutants.
    Manabu Ote, Morio Ueyama, Daisuke Yamamoto. Current Biology 26:2223–2232, 2016.
  18. A subset of neurons controls the permeability of the peritrophic matrix and midgut structure in Drosophila adults.
    Hiroyuki Kenmoku, Hiroki Ishikawa, Manabu Ote, Takayuki Kuraishi, Shoichiro Kurata. Journal of Experimental Biology 219:2331–2339, 2016.
  19. Clustered regulatory interspaced short palindromic repeats (CRISPR)-mediated mutagenesis and phenotype rescue by piggyBac transgenesis in a nonmodel Drosophila species.
    Ryoya Tanaka, Hina Murakami, Manabu Ote, Daisuke Yamamoto. Insect Molecular Biology 25:355–361, 2016.
  20. A fruitless upstream region that defines the species specificity in the male-specific muscle patterning in Drosophila.
    Sakino Takayanagi, Gakuta Toba, Tamas Lukacsovich, Manabu Ote, Kosei Sato, Daisuke Yamamoto. Journal of Neurogenetics 29:23–29, 2015.
  21. The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation.
    Shingo Kimura, Yasufumi Sakakibara, Kosei Sato, Manabu Ote, Hiroki Ito, Masayuki Koganezawa, Daisuke Yamamoto. Journal of Neurogenetics 29:8–17, 2015.
  22. Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
    Hiroki Ito, Kosei Sato, Masayuki Koganezawa, Manabu Ote, Ken Matsumoto, Chihiro Hama, Daisuke Yamamoto. Cell 149:1327–1338, 2012.
  23. fruitless specifies sexually dimorphic neural circuitry in Drosophila brain.
    Ken-ichi Kimura, Manabu Ote, Tatsunori Tazawa, Daisuke Yamamoto. Nature 438:229–233, 2005.
  24. Identification of molting fluid carboxypeptidase A (MF-CPA) in Bombyx mori.
    Manabu Ote, Kazuei Mita, Hideki Kawasaki, Takaaki Daimon, Masahiko Kobayashi, Toru Shimada. Comparative Biochemistry and Physiology Part B 141:314–322, 2005.
  25. Characteristics of two genes encoding proteins with an ADAM-type metalloprotease domain, which are induced during the molting periods in Bombyx mori.
    Manabu Ote, Kazuei Mita, Hideki Kawasaki, Masahiko Kobayashi, Toru Shimada. Archives of Insect Biochemistry and Physiology 59:91–98, 2005.
  26. Microarray analysis of gene expression profiles in wing discs of Bombyx mori during pupal ecdysis.
    Manabu Ote, Kazuei Mita, Hideki Kawasaki, Motoaki Seki, Junko Nohata, Masahiko Kobayashi, Toru Shimada. Insect Biochemistry and Molecular Biology 34:775–784, 2004.
  27. Change in the expressed gene patterns of the wing disc during the metamorphosis of Bombyx mori.
    Hideki Kawasaki, Manabu Ote, Kazuhiro Okano, Toru Shimada, Quan Guo-Xing, Kazuei Mita. Gene 343:133–142, 2004.
  28. Expression profiling of baculovirus genes in permissive and nonpermissive cell lines.
    Masashi Iwanaga, Kanzaburo Takaya, Susumu Katsuma, Manabu Ote, Shinichiro Tanaka, Shizuo George Kamita, WonKyung Kang, Toru Shimada, Masahiko Kobayashi. Biochemical and Biophysical Research Communications 323:599–614, 2004.
  29. Isolation and comparison of different ecdysone-responsive cuticle protein genes in wing discs of Bombyx mori.
    Takanori Noji, Manabu Ote, Masahisa Takeda, Kazuei Mita, Toru Shimada, Hideki Kawasaki. Insect Biochemistry and Molecular Biology 33:671–679, 2003.
  30. Characterization of the kynurenine 3-monooxygenase gene corresponding to the white egg 1 mutant in the silkworm Bombyx mori.
    Quan Guo-Xing, Insu Kim, Natuo Koumoto, Hideki Sezutsu, Manabu Ote, Toru Shimada, Toshio Kanda, Kazuei Mita, Masahiko Kobayashi, Toshiki Tamura. Molecular Genetics and Genomics 267:1–9, 2002.

著書・総説等

  1. 蚊のバイオロジー「微生物の力で蚊を制す─蚊に共生する微生物を利用した新たな感染症制御法」
    大手 学. 生物の科学 遺伝 5月号 No.3, 株式会社エヌ・ティー・エス, 2025.
  2. ボルバキアの繁栄を支えるRNAとの相互作用
    大手 学. 蚕糸・昆虫バイオテック 87巻3号, 日本蚕糸学会, 2018.