藤猪 英樹（ふじい ひでき）
職位：教授
略歴： 1993年北海道大学理学部高分子学科卒業
1998年北海道大学大学院理学研究科博士課程終了 博士（理学）
1998年富山医科薬科大学和漢薬研究所 研究員
1999年The Scripps Research
Institute, Department of Immunology
（La Jolla, USA）Research Associate
2002年国立感染症研究所 研究員
2005年慶應義塾大学医学部 微生物学・免疫学教室 助手・助教
2013年琉球大学医学部 免疫学講座 准教授
2017年徳島大学歯学部 口腔微生物学分野 教授
2022年慶應義塾大学医学部 生物学教室 教授
専門：免疫学、微生物学
担当学科目：生物学I、生物学実験
所属学会：日本細菌学会（評議委員）、日本免疫学会、日本ウイルス学会、
日本化学療法学会、日本HTLV-1学会
研究業績（直近10年）
【主要著書】
·
口腔微生物学・免疫学（第５版）、2021、医歯薬出版（分担執筆）
過敏症反応（アレルギー）と自己免疫疾患、免疫不全症
【主要論文】
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Putra Wigianto AY, Ishida Y, Iwawaki Y,
Goto T, Watanabe M, Sekine
K, Hamada K, Murakami K, Fujii H, Ichikawa T. 2-methacryloyloxyethyl phosphorylcholine polymer
treatment prevents Candida albicans biofilm formation on acrylic resin. J Prosthodont Res. 2022 Oct 27.
·
Okada N,
Murakami A, Sato M, Nakamura S, Fujii S, Sogabe K, Takahashi M, Okada A, Abe A, Fujii H, Abe M, Azuma M, Ishizawa K. First reported case of Lachnoanaerobaculum gingivalis
bacteremia in an acute myeloid leukemia patient with oral mucositis during high
dose chemotherapy. Anaerobe. 2022 Aug;76:102610.
·
Pahlevi MR,
Murakami K, Hiroshima Y, Murakami A, Fujii H. pruR and PA0065 Genes Are Responsible for
Decreasing Antibiotic Tolerance by Autoinducer Analog-1 (AIA-1) in Pseudomonas aeruginosa. Antibiotics. 2022 Jun 6;11(6):773.
·
Uemura Y,
Hiroshima Y, Tada A, Murakami K, Yoshida K, Inagaki Y, Kuwahara
T, Murakami A, Fujii H, Yumoto H. Porphyromonas gingivalis Outer Membrane Vesicles Stimulate Gingival Epithelial Cells to
Induce Pro-Inflammatory Cytokines via the MAPK and STING Pathways. Biomedicines. 2022 Oct 20;10(10):2643.
·
Abe N, Murakami K, Hiroshima Y, Amoh T, Sebe M, Kataoka K, Fujii H. Autoinducer analogs can provide
bactericidal activity to macrolides in pseudomonas aeruginosa through
antibiotic tolerance reduction. Antibiotice. 2022
11(1) Article number 10.
·
Nomura
H, Wada N, Takahashi H, Kase Y, Yamagami J, Egami S, Iriki H, Mukai M, Kamata A, Ito
H, Fujii H, Ishikura T, Koseki H, Watanabe T, Yamada T, Ohara O, Koyasu S, Amagai M. IgM
to IgG class-switching is a necessary step for pemphigus phenotype induction in
desmoglein 3-specific B cell receptor knock-in mouse.
J Immunol. 2022 208(3) 582-593.
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Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa
Isolated in the Respiratory Tract. Antibiotics.
2020 Sep 21;9(9):626.
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Heliyon. Suppressive effects of
2-methacryloyloxyethyl phosphorylcholine (MPC)-polymer on the adherence of Candida species
and MRSA to acrylic denture resin. Heliyon.2020 Jun 16;6(6):e04211.
·
The Pathogenic Factors from Oral Streptococci for
Systemic Diseases. Int J
Mol Sci. 2019 Sep 15;20(18):4571.
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Namkoong
H, Ishii M, Fujii H, Yagi
K, Asami T, Asakura T,
Suzuki S, Hegab AE, Kamata
H, Tasaka S, Atarashi K,
Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu
S, Betsuyaku T. Clarithromycin expands CD11b+Gr-1+
cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and
post-influenza bacterial pneumonia. PLoS Pathog. 2018 Apr 5;14(4):e1006955
·
Sekita Y, Murakami K, Yumoto H, Hirao K, Amoh T, Fujiwara N, Hirota K, Fujii H, Matsuo T, Miyake Y,
and Kashiwada Y. Antibiofilm and Anti-Inflammatory
Activities of Houttuynia cordata Decoction for Oral Care, Evid Based Complement
Alternat Med. 2017;Article ID 2850947, 10 pages
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Kunihiro M, Fujii
H, Miyagi T, Takahashi Y, Tanaka R, Fukushima T, Ansari AA, Tanaka Y. Heat Shock Enhances the
Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator
(Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells. Viruses. 2016
Jul 11;8(7). pii: E191
·
Fujii H, Shimizu M, Miyagi T, Kunihiro M, Tanaka R, Takahashi Y, Tanaka Y. A potential of
an anti-HTLV-1 gp46 neutralizing monoclonal antibody (LAT-27) for passive
immunization against both horizontal and mother-to-child vertical infection
with human T cell leukemia virus type-I. Viruses. 2016 Feb 3;8(2). pii:
E41.
·
Yagi K, Ishii M, Namkoong H, Fujii H, Asami T, Suzuki S, Asakura T,
Mizoguchi K, Kamo T, Tasaka
S, Chiba N, Ubukata K, Iwata S, Kunkel SL, Hasegawa
N, Betsuyaku T. Histone Deacetylase Inhibition Protects Mice
against Lethal Post-Influenza Pneumococcal Infection. Critical
Care Medicine. 2016 Jun 27.
·
KurodaY, Maruyama K, Fujii H,
Sugawara I, Ko S, Yasuda H, Matsui H, Matsuo K. Osteoprotegerin
regulates pancreatic β-cell homeostasis upon microbial invasion. PLOS
ONE. 2016 Jan 11;11(1):e0146544.
·
Human
T-cell leukemia virus type-I Tax induces the expression of CD83 on T cells. Retrovirology. 2015 Jul 1;12:56
·
Saito M,
Tanaka R, Fujii H, Kodama
A, Takahashi Y, Matsuzaki T, Takashima H, Tanaka Y.
The neutralizing function of the anti-HTLV-1 antibody is essential in
preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/c null
(NOG) mice. Retrovirology. 2014 Aug
28;11(1):74.
·
Yasui F, Kohara M, Kitabatake M, Nishiwaki T, Fujii H,
Tateno C, Yoneda M, Morita K, Matsushima K, Koyasu S, Kai C. Phagocytic cells contribute to the antibody-mediated
elimination of pulmonary-infected SARS coronavirus. Virology. 2014
Apr;454-455:157-68.
·
Tanaka
Y, Takahashi Y, Tanaka R, Kodama A, Fujii
H, Hasegawa A, Kannagi M, Ansari AA, Saito M.
Elimination of human T cell leukemia virus type-1 (HTLV-1)-infected
cells by neutralizing and ADCC-inducing antibodies against HTLV-1 envelope gp46. AIDS Res Hum Retroviruses. 2014 Jun;30(6):542-52.
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Asami T,
Ishii M, Fujii H, Namkoong
H, Tasaka S, Matsushita K, Ishii K, Yagi K, Fujiwara
H, Funatsu Y, Hasegawa N, Betsuyaku
T. Modulation of murine macrophage TLR7/8-mediated cytokine expression by mesenchymal stem
cell-conditioned medium. Mediat Inflamm. 2013 ;2013:264260